Publications


    1. Mutation timing in a spatial model of evolution (with J. Foo and J. Schweinsberg), submitted 2020. Link

    2. Understanding the role of phenotypic switching in cancer drug resistance (with S. De, J.Foo, and E. Gunnarsson), Journal of Theoretical Biology 2020. Preprint

    3. Splitting Algorithms for Rare Events of Semimartingale Reflecting Brownian motions (with X. Liu and Z. Wang), submitted 2019. Link

    4. Glioblastoma recurrence and the role of MGMT methylation (with K. Storey and et al.) JCO Clinical Cancer Informatics (2019). Link

    5. Optimizing chemoradiotherapy to target multi-site metastatic disease and tumor growth (with H. Badri, E. Salari, and Y. Watanabe), INFORMS Journal of Computing (2018). Link

    6. Combination therapeutics of Nilotinib and radiation in Acute Lymphoblastic Leukemia as an effective method against drug-resistance (with K. Kaveh and et al.), accepted PLoS Computational Biology (2017).

    7. Spatial measures of genetic heterogeneity during carcinogenesis (with K. Storey, M. Ryser and J. Foo), Bulletin of Mathematical Biology (2017). Link

    8. Quantifying the Dynamics of Field Cancerization in HPV-Negative Head and Neck Cancer: A Multiscale Modeling Approach (with M. Ryser, W. Lee, and J. Foo), Cancer Research (2016).

    9. Optimized treatment schedules for Chronic Myeloid Leukemia (with Q. He, J. Zhu, D. Dingli, and J. Foo), PLoS Computational Biology (2016). Link

    10. Optimal Treatment and Stochastic Modeling of Heterogeneous Tumors (with H. Badri), Biology Direct (2016). Link

    11. Rare-event analysis for extremal eigenvalues of white Wishart matrices (with T. Jiang and G. Xu), accepted Annals of Statistics (2016). Link

    12. A mathematical model of tumor growth and its response to single irradiation (with Y. Watanabe, E. Dahlman and S. Hui), Theoretical Biology and Medical Modelling (2016).

    13. Robust and probabilistic optimization of dose schedules in radiotherapy (with H. Badri and Y. Watanabe), Physics in Medicine and Biology (2015). Link

    14. Minimizing Metastatic Risk in Radiotherapy Fractionation Schedules (with H. Badri and J. Ramakrishnan), Physics in Medicine and Biology (2015). Link

    15. The impact of microenvironmental heterogeneity on the evolution of drug resistance in cancer cells (with S. Mumenthaler and et al.) Cancer Informatics (2015).

    16. Spatial Moran Models II. Cancer initiation in spatially structured tissue (with R. Durrett and J. Foo), Jour Math Biol (2015).

    17. Optimization of Radiation Dosing Schedules for Proneural Glioblastoma (with H. Badri and et. al.), Jour Math Biol (2015).

    18. Evolutionary dynamics of driver and passenger mutations during tumorigenesis (with J. Foo and et al), PLoS Computational Biology (2015).

    19. Escape times for branching processes with random mutational fitness effects (with J. Foo and J. Zhu), Stochastic Processes and Their Applications (2014). PDF

    20. Multifocality and recurrence risk: a quantitative model of field cancerization (with J. Foo and M. Ryser), Journal of Theoretical Biology (2014). Link

    21. Mathematical modeling of proneural glioblastoma reveals optimized radiation dosing schedules (with K. Pitter, E. Holland, F. Michor and et al),Cell (2014). Link

    22. Importance sampling for stochastic recurrence equations with heavy tailed innovations (with J. Blanchet and H. Hult), ACM TOMACS (2013).

    23. Cancer as a moving target (with J. Foo and S. Mumenthaler), Evolutionary Applications (2013)

    24. Dynamics of Cancer Recurrence (with J. Foo), Annals of Applied Probability (2013). PDF

    25. On Lyapunov inequalities and subsolutions for efficient importance sampling (with J. Blanchet and P. Glynn), ACM TOMACS (2011). PDF

    26. Evolutionary modeling of combination strategies to over-come resistance to tyrosine kinase inhibitors in non-small cell lung cancer (with J. Foo and et al), Molecular Pharmaceutics (2011)

    27. Diversity in pre-existing resistance to BCR-ABL inhibitors in chronic myeloid leukemia (with J. Foo, B. Skaggs, M.E. Gorre, C. Sawyers, and F. Michor), PLOS ONE (2011).

    28. Heterogeneity in tumors with random mutational advances (with R. Durrett, J. Foo, J. Mayberry and F. Michor), Genetics (2010). PDF

    29. Analysis of a splitting estimator for rare event probabilities in Jackson Networks (with J. Blanchet and Y. Shi), Stochastic Systems (2011). PDF

    30. The therapeutic implications of plasticity of the cancer stem cell phenotype (with E. Holland and F. Michor), PLOS ONE (2010).

    31. Stochastic dynamics of cancer initiation (with J. Foo and F. Michor), Physical Biology (2010).

    32. Evolutionary dynamics of tumor progression with random fitness values (with R. Durrett, J. Foo, J. Mayberry, and F. Michor) Theoretical Population Biology (2010).

    33. Strongly efficient algorithms for light-tailed random walks: An old folk song sung to a faster new tune... (with J. Blanchet and P. Glynn) Monte Carlo and Quasi-Monte Carlo Methods (2009).

    34. Importance sampling for the weighted serve the longest queueing policy (with P. Dupuis and H. Wang) Mathematics of Operations Research (2009). PDF

    35. On the Large Deviations Properties of the Weighted-Serve-the-Longest Queue Policy (with P. Dupuis and H. Wang) Progress in Probability (2008). PDF

    36. Large deviations and importance sampling for a tandem network with slow-down. (with P. Dupuis and H. Wang) Queueing Systems (2007). PDF

    37. Importance sampling for sums of random variables with regularly varying tails (with P. Dupuis and H. Wang) ACM Transactions on Modeling and Computer Simulation (2007).